Cast of The Venture Bros.

Doc Hammer provides the voice for two characters in The Venture Bros. He voices Dr. Girlfriend, a supervillain and the love interest of The Monarch. He also voices Henchman 21, a former henchman turned vigilante.

Christopher McCulloch, also known by his pseudonym Jackson Publick, voices two main characters in The Venture Bros. He voices Hank Venture, one of the titular brothers in the show who is eager and adventurous. He also voices The Monarch, a butterfly-themed supervillain and the arch-nemesis of Dr. Venture.

Patrick Warburton lends his voice to the character of Brock Samson, a bodyguard and former secret agent who is tasked with protecting the Venture family. Brock is known for his strength, combat skills, and deadpan humor.

James Urbaniak voices the character of Dr. Venture, the patriarch of the Venture family and a renowned scientist. Dr. Venture is often portrayed as socially awkward and is constantly inventing new gadgets and inventions.

Michael Sinterniklaas provides the voice for Dean Venture, the younger brother of Hank Venture. Dean is depicted as intellectual and sensitive, often serving as the more rational counterpart to his brother's adventurous nature.

Patton Oswalt voices the character of Wonderboy, a superhero and former sidekick of Captain Sunshine. Wonderboy possesses superhuman strength and agility, and his character adds a comedic element to the show.

H. Jon Benjamin provides the voice for The Master, a martial arts expert and member of The Guild of Calamitous Intent. The Master is known for his dry and sarcastic wit, and his character often interacts with other villains in the show.

Nathan Fillion voices the character of Brown Widow, a parody of Spider-Man. Brown Widow is a former superhero who becomes a mentor figure to some of the younger characters in the show.