Maniac (TV) Cast
The cast of Maniac. Updated on October 2, 2025.
66 actors
Emma Stone
as Annie Landsberg (10 episodes)

Emma Stone portrays the character of Annie Landsberg in the TV show Maniac. Annie is a troubled young woman who becomes involved in a promising but secretive pharmaceutical trial.

Jonah Hill
as Owen Milgrim (10 episodes)

Jonah Hill plays the character of Owen Milgrim in the TV show Maniac. Owen is a socially awkward and paranoid man who volunteers for the same pharmaceutical trial as Annie.

Sonoya Mizuno
as Dr. Azumi Fujita (10 episodes)

Sonoya Mizuno portrays the character of Dr. Azumi Fujita in the TV show Maniac. Dr. Fujita is one of the scientists conducting the pharmaceutical trial and plays a crucial role in the experiment.

Ramya Pratt
as Vicky / Green Hoodie Woman (3 episodes)
Maho Honda
as Intake Tech (2 episodes)
Justin Theroux
as Dr. James K. Mantleray (10 episodes)

Justin Theroux plays the character of Dr. James K. Mantleray in the TV show Maniac. Dr. Mantleray is a brilliant but eccentric researcher who develops the pharmaceutical trial and oversees the participants.

Sally Field
as Dr. Greta Mantleray (10 episodes)

Sally Field portrays the character of Dr. Greta Mantleray in the TV show Maniac. Dr. Mantleray is the mother of Dr. James K. Mantleray and has her own complicated relationship with the pharmaceutical trial.

Lauren E. Banks
as Winged Nymph (1 episode)

Lauren E. Banks plays the character of the Winged Nymph in the TV show Maniac. The Winged Nymph is a mysterious and mythical character in the experiment who interacts with Annie and Owen.

Jacqueline Grabois
as Annie's Roommate (2 episodes)
Aaralyn Anderson
as Belle Milgrim (5 episodes)
Eric T. Miller
as Daddy's Here Operator (1 episode)

Eric T. Miller portrays two characters in the TV show Maniac. He plays the role of the Daddy's Here Operator, who is in charge of monitoring the participants in the pharmaceutical trial. He also plays the character of Douglas on the Radio, who provides guidance and support to the participants.

Marlene Ginader
as Beth Sanders (2 episodes)
Lindsey Blanchard
as Little Ellie (1 episode)
Marcus Toji
as Calvin (1 episode)
Rob Yang
as Matt Ming (1 episode)
Ben Sinclair
as (1 episode)
Elaine Bromka
as (1 episode)
Rob DeRosa
as (1 episode)
Zach Shearon
as Young Boy in a Truck (1 episode)
Jennifer Ikeda
as (1 episode)
Subhash Mandal
as (1 episode)
Tony Manna
as (1 episode)
Sean Meehan
as General Nathan Banner (1 episode)
Louis Arcella
as Portuguese General (1 episode)
Lukas Hassel
as Danish General (1 episode)
Min-wen Huang
as (1 episode)
Olivia Whelan
as (1 episode)
Leo Fitzpatrick
as Lance (2 episodes)
Glenn Fleshler
as (1 episode)
Jojo Gonzalez
as Agent Lopez (2 episodes)
Alexandra Henrikson
as (1 episode)
Alix Korey
as (1 episode)
Maxine Prescott
as Mrs. Finkelstein (2 episodes)
Joseph Sikora
as JC (2 episodes)
David Fierro
as Ad Buddy (2 episodes)
Hank Azaria
as Hank Landsberg (voice) (3 episodes)
Glenn Wein
as (1 episode)
Chris Ghaffari
as Julio (1 episode)
Trudie Styler
as Angelica Milgrim (4 episodes)
Ariel Kavoussi
as Female Ad Buddy / Bianca Forsythe / Dragonfly (voice) (3 episodes)
Jonathan Rentler
as (2 episodes)
Laura Marie Steigers
as Nurse (1 episode)
James Monroe Iglehart
as Carl (8 episodes)
Dai Ishiguro
as Head Control Tech (8 episodes)
Sissy Sheridan
as (1 episode)
Selenis Leyva
as Patricia Lugo (3 episodes)
Lev Gorn
as Sokolov (3 episodes)
Mike Masters
as (2 episodes)
Josh Pais
as Andy (3 episodes)
Gabriel Byrne
as Porter Milgrim (5 episodes)
Kathleen Choe
as 3 (9 episodes)
Christian DeMarais
as Mike Milgrim (4 episodes)
Grace Van Patten
as Olivia Meadows (3 episodes)
Allyce Beasley
as 11 (8 episodes)
Cailin Loesch
as Lady of Arquesta (4 episodes)
Hannah Loesch
as Lady of Arquesta (4 episodes)
Stephen Hill
as 7 (8 episodes)
Jemima Kirke
as Adelaide (5 episodes)
Geoffrey Cantor
as Frank (4 episodes)
Danny Hoch
as 5 (9 episodes)
Rome Kanda
as Dr. Muramoto (4 episodes)
Julia Garner
as Ellie Landsberg (5 episodes)
Billy Magnussen
as Jed Milgrim (7 episodes)
Nate Craig
as Phil (5 episodes)
Alexandra Curran
as Holly Milgrim (5 episodes)
Sejal Shah
as First Medical Tech (8 episodes)
For the best insights and data about the TV show Maniac, visit our main Maniac page.