Lessons in Chemistry (TV) Cast
The cast of Lessons in Chemistry. Updated on October 2, 2025.
129 actors
Brie Larson
as Elizabeth Zott (8 episodes)

Brie Larson portrays the character of Elizabeth Zott, a brilliant scientist who faces personal and professional challenges. Larson's impeccable acting skills bring depth and complexity to Elizabeth's character, capturing her determination and intelligence.

Lewis Pullman
as Calvin Evans (8 episodes)

Lewis Pullman plays the role of Calvin, a significant character in Lessons in Chemistry. Pullman's portrayal adds intrigue and charisma to Calvin, making him a captivating presence on screen.

Aja Naomi King
as Harriet Sloane (8 episodes)

Aja Naomi King takes on the role of Harriet Sloane, bringing her captivating presence and stellar acting skills to the character. King's performance adds layers of emotion and depth to Harriet's story.

Stephanie Koenig
as Fran Frask (8 episodes)

Stephanie Koenig portrays Fran Frask, a character who adds humor and wit to the series. Koenig's comedic timing and talent shine through in her portrayal of Fran.

Patrick Walker
as Curtis Wakely (8 episodes)

Patrick R. Walker portrays Wakely in Lessons in Chemistry. Walker's performance brings intensity and depth to the character, creating a captivating presence on screen.

Thomas Mann
as Boryweitz (8 episodes)

Thomas Mann brings his acting prowess to the character of Boryweitz, adding complexity and relatability to the role. Mann's performance adds depth to the dynamics within the show.

Beau Bridges
as Wilson (8 episodes)

Beau Bridges plays the role of Wilson, a significant character in the series. Bridges' seasoned acting skills and charismatic presence make Wilson a compelling and memorable character.

Kevin Sussman
as Walter (8 episodes)

Kevin Sussman takes on the role of Walter, showcasing his talent for delivering humorous and memorable performances. Sussman's portrayal adds a unique flavor to the show.

Rainn Wilson
as Phil Lebensmal (4 episodes)
Derek Cecil
as Dr. Robert Donatti (5 episodes)
Andy Daly
as Dr. Richard Price (4 episodes)
Adam Bartley
as Scientist (3 episodes)
Joshua Hoover
as Anthony Powers (4 episodes)
Brandon Gibson
as Tom Clemens (3 episodes)
Robert Alan Beuth
as Frank Marsten (3 episodes)
Ali Kinkade
as Jenny Marie Kay (2 episodes)
Sigi Ravet
as Laurel Moore (3 episodes)
Debbie Pollack
as Louise (3 episodes)
Valentina Garcia
as Nancy Donatti (1 episode)
Laura Siegel
as Bertha Clifton (3 episodes)
Gregg Brown
as Director (3 episodes)
John Alton
as Stage Manager (3 episodes)
Eileen Álvarez
as Hair Stylist (1 episode)
Isaac Jay
as Production Assistant / Harry the PA (3 episodes)
Caroline Cole
as Charlene Ogilvy (2 episodes)
Yasir Lafond
as James 'Junior' Sloane (4 episodes)
Amentii Sledge
as Linda Sloane (4 episodes)
Tate Ellington
as Dr. Bates (1 episode)
James Gleason
as Chairman of the Board (3 episodes)
Michael James Bell
as Highway Suit (1 episode)
Brandon Gobson
as Tom Clemens (1 episode)
Troy Vincent
as UCLA Professor (1 episode)
Pamela Shafer
as Associate Dean (1 episode)
Kent Hagen
as City Council Chairman (1 episode)
B.J. Novak
as Six-Thirty (voice) (1 episode)
Jake Short
as Ralph Bailey (1 episode)
Marc Evan Jackson
as Dr. Leland Mason (6 episodes)
Nicolas Coster
as Paul Astor (1 episode)
Barry Livingston
as Pastor (1 episode)
Alex Boling
as Oocyte Chemist (1 episode)
Lee Eisenberg
as Funeral Director (1 episode)
Brian Leckner
as Businessman (1 episode)
Cameron Fay
as Police Officer (1 episode)
Aaron Coleman
as Harriet's Colleague (1 episode)
Paul James
as Charlie Sloane (5 episodes)
Alice Halsey
as Madeline 'Mad' Zott (5 episodes)
Caryn West
as Mrs. Mudford (2 episodes)
Shoo Shoo Parsells
as Amanda Pine (3 episodes)
Phoebe Kuhlman
as Nurse (1 episode)
Kandis Fay
as New Mother (1 episode)
Jonney Ahmanson
as Baseball Fan (1 episode)
Steven Pritchard
as Whiskey Guy (1 episode)
Tyler Beardsley
as Magazine Shredder (1 episode)
Sherry Larson
as Gerta Borgnino (1 episode)
Constance Ejuma
as Agnes (2 episodes)
Keena Ferguson
as Rhoda (2 episodes)
Danny Brown
as Jodie (1 episode)
Maya Malan-Gonzalez
as Wailing Woman (1 episode)
Jeff Marlow
as Bank Manager (1 episode)
Casey Feigh
as Moving Supervisor (1 episode)
Hannah Horton
as Walter's Secretary / Walter's Secretary - Joan (2 episodes)
Indiana Elle
as Bully #1 (1 episode)
Alana Gay
as Linda Sloane (3 episodes)
Hero Hunter
as James 'Junior' Sloane (3 episodes)
Lola Kelly
as Housewife (1 episode)
Amanda Walsh
as Waitress (1 episode)
Catherine Hyslop
as Bully #2 (1 episode)
Todd Aaron Brotze
as Consultant (1 episode)
Lauren Cook
as Rebecca (2 episodes)
Joy Jacobson
as Shari (3 episodes)
Alex Staggs
as Sound Mixer (1 episode)
Julianne Buescher
as Secretary (1 episode)
Kameron Brummer
as Tommy (1 episode)
Daniele O'Loughlin
as Harried Mother (1 episode)
Dexter Alvarez
as Crazy Kid #1 (1 episode)
Luke Alvarez
as Crazy Kid #2 (1 episode)
Nathan Caywood
as Male Audience Member #1 (1 episode)
Jonathan Fishman
as Male Audience Member #2 (1 episode)
Herbert Russell
as Male Audience Member #3 (1 episode)
James Vincent
as Male Audience Member #4 (1 episode)
Tammy Caplan
as Female Audience Member #1 (1 episode)
Jessy Greer
as Female Audience Member #2 (1 episode)
Jackson Kelly
as John Zott (1 episode)
Jon Fletcher
as Ezra Zott (1 episode)
Ridley Haitkin
as Young Elizabeth Zott (1 episode)
Danielle Hoetmer
as Iris Zott (1 episode)
Ben Shields
as Mayor Van Veen (1 episode)
Tunisia Hardison
as Marge (1 episode)
Annie O'Donnell
as Mrs. Eugenia Waterhouse (1 episode)
Chanté Bowser
as Suz (1 episode)
Steven Connor
as Jameson (1 episode)
Tristen MacDonald
as Mrs. Fillis (2 episodes)
Carson Zone
as Mayor's Son (1 episode)
Meredith Jackson
as Mayor's Wife (1 episode)
Vaughndio Forbes
as Sanford (1 episode)
Dan Sachoff
as Reporter (1 episode)
Gaye Coffman
as Librarian (1 episode)
Laura Hurst
as Shirley (1 episode)
David Lee Hess
as Rheumy Eyes (1 episode)
Lon Gowan
as Head Cop Stunt #1 (1 episode)
For the best insights and data about the TV show Lessons in Chemistry, visit our main Lessons in Chemistry page.