Big Mouth (TV) Cast
The cast of Big Mouth. Updated on October 2, 2025.
120 actors
Nick Kroll
as Nick Birch / Maury the Hormone Monster / Coach Steve (voice) (71 episodes)

Nick Kroll brings several characters to life in Big Mouth. He portrays Nick Birch, a teenage boy who navigates the ups and downs of puberty. He also voices Maury the Hormone Monster, a mythical creature who serves as a guide and mentor to Nick. Additionally, Kroll lends his voice to Coach Steve, a well-meaning but clueless gym teacher.

John Mulaney
as Andrew Glouberman (voice) (71 episodes)

John Mulaney lends his voice to Andrew Glouberman, Nick's best friend. Andrew is also going through puberty and faces his own set of challenges and insecurities. Mulaney's portrayal brings humor and relatability to the character.

Jessi Klein
as Jessi Glaser (voice) (71 episodes)

Jessi Klein voices Jessi Glaser, a smart and self-aware teenage girl. Jessi deals with the struggles of adolescence and grapples with her changing body and emotions. Klein's performance brings depth and authenticity to Jessi's character.

Jenny Slate
as Missy Foreman-Greenwald (voice) (41 episodes)

Jenny Slate portrays Missy Foreman-Greenwald, a kind-hearted and intelligent girl who is also going through puberty. Missy is a loyal friend to Nick and Jessi and provides a unique perspective on the challenges of growing up. Slate's voice brings warmth and charm to the character.

Jason Mantzoukas
as Jay Bilzerian (voice) (71 episodes)

Jason Mantzoukas voices Jay Bilzerian, a wild and outrageous teenage boy. Jay is known for his crude humor and mischievous behavior. Mantzoukas' energetic performance enhances the comedic aspects of Jay's character.

Maya Rudolph
as Diane Birch / Constance the Hormone Monstress (voice) (71 episodes)

Maya Rudolph lends her voice to Diane Birch, Nick's mother, and Constance the Hormone Monstress. Diane is a caring and supportive parent who tries her best to understand Nick's struggles. Constance, on the other hand, is a sassy and provocative Hormone Monstress who guides Nick through the complexities of puberty. Rudolph's versatile voice brings both warmth and sensuality to her characters.

Fred Armisen
as Elliot Birch (voice) (71 episodes)

Fred Armisen voices Elliot Birch, Nick's father. Elliot is a loving and somewhat eccentric dad who provides guidance and support to Nick. Armisen's delivery adds a touch of quirkiness to Elliot's character.

Jordan Peele
as Ghost of Duke Ellington (voice) (71 episodes)

Jordan Peele voices the Ghost of Duke Ellington in Big Mouth. The Ghost of Duke Ellington provides musical commentary and guidance to the characters. Peele's voice talents bring a unique and captivating presence to the character.

Andrew Rannells
as Matthew MacDell (voice) (51 episodes)
Ayo Edebiri
as Missy Foreman-Greenwald (voice) (31 episodes)
Brandon Kyle Goodman
as Walter the Lovebug (voice) (10 episodes)
Jon Hamm
as Scallops (voice) (1 episode)
Kristen Bell
as Pam the Pillow (voice) (3 episodes)
Jon Gabrus
as Movie Theater Customer (voice) (1 episode)
Anna Graves
as Mrs. Albert (voice) (1 episode)
Nasim Pedrad
as Fatima (voice) (1 episode)
Mae Whitman
as Tallulah Levine (voice) (1 episode)
Zach Woods
as Daniel (voice) (1 episode)
Chrissy Guerrero
as Choir Girl (voice) (1 episode)
Craig Robinson
as Pubic Hair #2 (voice) (2 episodes)
Philip Quinaz
as Tanya Alvarez (voice) (1 episode)
Ashley London
as Skank (voice) (1 episode)
John Gemberling
as Tyler the Hormone Monster (voice) (3 episodes)
Joe Wengert
as Caleb (voice) (7 episodes)
Harvey Fierstein
as Older Guy Town Resident (voice) (1 episode)
Jerry Minor
as Man #3 / Singing Fish (voice) (1 episode)
Gil Ozeri
as Brad (voice) (2 episodes)
Mark Rivers
as (voice) (3 episodes)
Natasha Lyonne
as Suzette (voice) (3 episodes)
Piotr Michael
as Siamese Twin #2 (voice) (1 episode)
Ileen Goldsmith
as Jessi Glaser - singing double / Judd's Girlfriend (voice) (1 episode)
Marisa Lark Wallin
as Reese's Wertherspoon / Woman (voice) (1 episode)
Emily Altman
as Vicky (voice) (2 episodes)
Crissy Guerrero
as (voice) (1 episode)
David Thewlis
as Shame Wizard (voice) (8 episodes)
Brendan McCreary
as Freddie Mercury (singing voice) (1 episode)
Andy Daly
as Ghost of Harry Houdini (voice) (1 episode)
Martin Short
as Gordie (voice) (1 episode)
Carlos Alazraqui
as Gustavo (voice) (2 episodes)
Nathan Fillion
as Nathan Fillion (voice) (7 episodes)
Neil Casey
as Lars (voice) (10 episodes)
David Cross
as Skip Glouberman (voice) (1 episode)
Carol Kane
as Menopause Banshee / Old Woman (voice) (1 episode)
Michaela Watkins
as Cantor Dina Reznick (voice) (5 episodes)
Julie Klausner
as Cherry Marashina (voice) (2 episodes)
Tawny Newsome
as (voice) (1 episode)
Chris Redd
as (voice) (2 episodes)
Retta
as Duke's Mother (voice) (1 episode)
Fran Gillespie
as (voice) (2 episodes)
Wanda Sykes
as Ghost of Harriet Tubman (voice) (1 episode)
Chelsea Peretti
as Monica Foreman-Greenwald (voice) (8 episodes)
Jessica Chaffin
as Shannon Glaser / Grace / Intellect Sphinx (voice) (1 episode)
Jaboukie Young-White
as (voice) (1 episode)
Rosa Salazar
as Ms. Benitez (voice) (4 episodes)
Rob Riggle
as Sgt. Adderall (voice) (1 episode)
Bobby Berk
as Bobby Berk (voice) (1 episode)
Paula Pell
as Barbara Glouberman (voice) (16 episodes)
Karamo Brown
as Karamo Brown (voice) (1 episode)
Bobby Cannavale
as Gavin (voice) (1 episode)
Tan France
as Tan France (voice) (1 episode)
Rob Huebel
as Mr. Lizer (voice) (6 episodes)
Gary Cole
as (1 episode)
Antoni Porowski
as Antoni Porowski (voice) (1 episode)
Jonathan van Ness
as Jonathan Van Ness (voice) (1 episode)
Jak Knight
as DeVon (voice) (16 episodes)
Anna Konkle
as Izzy (voice) (1 episode)
Maya Erskine
as Misha (voice) (1 episode)
Thandiwe Newton
as Mona (voice) (4 episodes)
John Oliver
as Harry (voice) (3 episodes)
Kat Dennings
as Leah Birch (voice) (14 episodes)
Seth Rogen
as Seth Goldberg (voice) (3 episodes)
Paul Scheer
as Kurt Bilzerian (voice) (6 episodes)
Alia Shawkat
as Roland (voice) (1 episode)
Jon Daly
as Judd Birch (voice) (15 episodes)
Josie Totah
as Natalie (voice) (2 episodes)
Lena Waithe
as Lena (voice) (2 episodes)
Gina Rodriguez
as Gina Alvarez (voice) (13 episodes)
Seth Morris
as Greg Glaser (voice) (12 episodes)
Paul Giamatti
as Andrew’s Shit (voice) (1 episode)
Julie White
as Kimberly (voice) (2 episodes)
Heather Lawless
as Jenna Bilzerian (voice) (11 episodes)
June Diane Raphael
as Devin (voice) (18 episodes)
Ali Wong
as Ali (voice) (5 episodes)
Sterling K. Brown
as Michael Angelo (voice) (2 episodes)
Maria Bamford
as Tito the Anxiety Mosquito (voice) (5 episodes)
Quinta Brunson
as Quinta (voice) (2 episodes)
Jean Smart
as Depression Kitty (voice) (5 episodes)
Kristen Wiig
as Jessi's Vagina (voice) (3 episodes)
Zachary Quinto
as Aiden (voice) (7 episodes)
Adam Scott
as Mr. Keating (voice) (1 episode)
Hugh Jackman
as himself (voice) (1 episode)
Kumail Nanjiani
as himself (voice) (1 episode)
Keke Palmer
as Rochelle the Hate Worm (voice) (1 episode)
Jemaine Clement
as Simon Sex (voice) (1 episode)
Kristen Schaal
as Bernie Sanders (voice) (1 episode)
Jack McBrayer
as Pubic Hair #1 (voice) (5 episodes)
Aidy Bryant
as Emmy (voice) (1 episode)
Mark Duplass
as Val Bilzerian (voice) (9 episodes)
Joel Kim Booster
as Charles Lu (voice) (2 episodes)
Richard Kind
as Marty Glouberman (voice) (23 episodes)
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