Whoopi Goldberg voices Ranger Margaret, a character who plays a key role in the Rugrats' journey.
David Spade provides the voice for Ranger Frank, a character who interacts with the Rugrats during their adventure.
Elizabeth Daily voices the iconic character Tommy Pickles, the fearless and adventurous leader of the Rugrats gang.
Tara Strong lends her voice to Dilan 'Dil' Pickles, the youngest member of the Rugrats family.
Christine Cavanaugh voices Chuckie Finster, the lovable and anxious friend of Tommy Pickles.
Kath Soucie voices multiple characters including Phil, Lil, and Betty DeVille, adding distinctive personalities to the Rugrats group.
Cheryl Chase portrays the spirited Angelica Pickles, the feisty cousin of Tommy and Dil.
Tim Curry lends his voice to Rex Pester, a character who adds an element of intrigue and excitement to the Rugrats' adventure.
Jack Riley voices Stuart 'Stu' Pickles, the inventive father of Tommy and Dil Pickles.
Busta Rhymes provides the voice for Reptar Wagon, a fun and entertaining addition to the movie.
Michael Bell voices Charles 'Chaz' Finster Sr., Grandpa Boris Kropotkin, and Drew Pickles, adding depth to multiple characters in the Rugrats universe.
Joe Alaskey portrays Grandpa Lou Pickles, the wise and caring grandfather of Tommy and Dil Pickles.
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