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I Know This Much Is True
Cast
80 cast members · 27 with popularity data
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Episode Ratings
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Full Cast
Sorted by Buzz Score · April 29, 2026
1
Juliette Lewis
Nedra Frank
· 2 eps
3.1
#1,430 overall
2
Mark Ruffalo
Dominick Birdsey / Thomas Birdsey
· 6 eps
3.1
#1,444 overall
3
Imogen Poots
Joy Hanks
· 3 eps
2.2
#2,400 overall
4
Rosie O'Donnell
Lisa Sheffer
· 6 eps
2.0
#2,666 overall
5
Kathryn Hahn
Dessa Constantine
· 6 eps
1.9
#2,788 overall
6
Bruce Greenwood
Dr. Hume
· 2 eps
1.4
#3,954 overall
7
Tatanka Means
Nabby Drinkwater
· 2 eps
1.2
#4,707 overall
8
Melissa Leo
Concettina Ipolita Tempesta 'Ma' Birdsey
· 6 eps
1.2
#4,820 overall
9
Archie Panjabi
Dr. Patel
· 6 eps
1.1
#5,422 overall
10
Laura Silverman
Kristin
· 1 eps
0.6
#8,648 overall
11
Aisling Franciosi
Young Dessa Constantine
· 2 eps
0.6
#9,249 overall
12
Rob Huebel
Leo
· 6 eps
0.4
#11,445 overall
13
Harris Yulin
Father Lavie
· 1 eps
0.4
#11,667 overall
14
Guillermo Díaz
Sergeant Mercado
· 1 eps
0.4
#12,142 overall
15
Destry Allyn Spielberg
Dr. Hume's Daughter
· 1 eps
0.4
#12,932 overall
16
Felix Solis
Nurse
· 1 eps
0.3
#14,270 overall
17
Michael Greyeyes
Ralph Drinkwater
· 6 eps
0.2
#19,351 overall
18
Brian Goodman
Al
· 1 eps
0.1
#22,397 overall
19
Marylouise Burke
Librarian
· 1 eps
0.1
#24,561 overall
20
Joe Grifasi
Steve Falice
· 1 eps
0.1
#29,951 overall
21
Philip Ettinger
Early Adulthood Dominick Birdsey / Thomas Birdsey
· 2 eps
0.1
#30,501 overall
22
Brandon J. Dirden
Kyle's Dad
· 1 eps
0.0
#35,274 overall
23
Christopher J. Hanke
Thad
· 1 eps
0.0
#46,165 overall
24
Michael Genet
Thomas' Surgeon
· 1 eps
0.0
#52,123 overall
25
Laura Esterman
Ruth Hood
· 3 eps
0.0
#53,840 overall
26
Marcello Fonte
Domenico Onofrio Tempesta
· 2 eps
0.0
#55,665 overall
27
Gina Costigan
Mrs. O'Meara
· 1 eps
0.0
#60,471 overall
28
John Procaccino
Ray Birdsey
· 6 eps
—
29
Gabe Fazio
Shawn Tudesco / Dominick and Thomas Acting Double
· 6 eps
—
30
Sue Jean Kim
Dr. Yup
· 1 eps
—
31
Michael Simon Hall
Stuart Feinstein
· 1 eps
—
32
Steven Cox
Boyfriend of Dr. Hume's Daughter
· 1 eps
—
33
MorningStar Angeline
Nabby Drinkwater's Wife
· 1 eps
—
34
Al Linea
Abruzzi
· 1 eps
—
35
Richard Fitch
Mill Foreman
· 1 eps
—
36
Amy Lynn Stewart
Merciful Mother
· 1 eps
—
37
Tim Ruddy
Robocop
· 1 eps
—
38
Sandra Berrios
Social Worker at Hatch
· 1 eps
—
39
Christine Parks
Humanities Department Chair
· 1 eps
—
40
Morgan Sullivan
Office Buddy
· 1 eps
—
41
Jake Robards
Landlubbers (voice)
· 1 eps
—
42
María Gonzalez
Ma's Oncology Nurse
· 1 eps
—
43
A.C. Peterson
Gene Diogenes
· 1 eps
—
44
James Quattrochi
Bus Driver
· 1 eps
—
45
Rachel B. Joyce
Jeanette
· 1 eps
—
46
Paul Coleman
Support Group Counselor
· 1 eps
—
47
Katt Masterson
Doreen
· 1 eps
—
48
Jason Furlani
Larry Penn
· 1 eps
—
49
Annie Fitzgerald
Miss Hanker
· 2 eps
—
50
Kate Grimes
English Professor
· 1 eps
—
51
Joseph Ragno
Henrey Rood
· 1 eps
—
52
Acahkos Johnson
Penny Ann Drinkwater
· 2 eps
—
53
Jaiden Klein
Marie Sexton
· 2 eps
—
54
Charlie Reina
Channy
· 2 eps
—
55
Violet Adams
Bunny Borsa
· 2 eps
—
56
Oliver Patnode
Otero
· 2 eps
—
57
Chelsea Sheets
Brunette
· 1 eps
—
58
Matt Helm
Young Leo
· 2 eps
—
59
Derek Goh
17-19 Year Old Dominick & Thomas Acting Double
· 2 eps
—
60
Raymond Neil Hernandez
Omar
· 1 eps
—
61
Simone Coppo
Vincenzo Tempesta
· 1 eps
—
62
Sean Cullen
Dr. Yates
· 1 eps
—
63
Federico Dordei
Nunzio Tucci
· 1 eps
—
64
Agatha Nowicki
Angie Constantine
· 2 eps
—
65
Rocco Masihi
Young Thomas Birdsey
· 4 eps
—
66
Irene Muscara
Prosperina Tucci
· 2 eps
—
67
Adrienne R. Williams
Mrs. Birdsall
· 2 eps
—
68
Shannon Plumb
Charlotte
· 1 eps
—
69
Donnie Masihi
Young Dominick Birdsey
· 4 eps
—
70
Zaria Degenhardt
11 Year Old Concettina
· 1 eps
—
71
Mark A. Gamma
Mourner Mark
· 1 eps
—
72
Wayne J. Miller
Mourner Wayne
· 1 eps
—
73
Thomas Gionet-Lavigne
Ray's Orderly
· 1 eps
—
74
Alexander Hacker
Templeton
· 1 eps
—
75
Robert Mladinich
Paddy Wagon Officer
· 1 eps
—
76
Roberta Riganò
Ignazia Tempesta
· 1 eps
—
77
Tim Ruddy
Robocop
· 1 eps
—
78
Ethan Crystal
Thin Sailor
· 1 eps
—
79
James Pravasilis
Third Guard
· 1 eps
—
80
Michael Armand DeMatteo
Fatso
· 1 eps
—
I Know This Much Is True Stats
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