A.P. Bio Cast

Glenn Howerton plays Jack Griffin, an ex-philosophy professor who teaches A.P. Bio.

Lyric Lewis portrays Stef, one of the enthusiastic teachers at Whitlock High School.

Mary Sohn plays Mary, a high-spirited teacher at the school.

Jean Villepique is Michelle, another vibrant teacher at Whitlock High.

Tom Bennett takes on the role of Miles, Jack's rival.

Patton Oswalt is Principal Durbin, the well-meaning principal of Whitlock High.

Aparna Brielle plays Sarika, a brilliant student in Jack's class.

Sari Arambulo portrays Grace, a student in the A.P. Bio class.

Paula Pell plays Helen Henry Demarcus, the secretary at Whitlock High.

Ronnie Alvarez appears as the Waiter.

Tim Heidecker plays Greg Miller.