Twice in a Lifetime Cast

Gene Hackman portrays Harry MacKenzie, a man going through a midlife crisis and questioning his life choices.

Ann-Margret takes on the role of Audrey Minelli, the mistress of Harry MacKenzie.

Ellen Burstyn plays Kate MacKenzie, the wife of Harry MacKenzie, who faces challenges in their relationship.

Amy Madigan portrays Sunny, a character who becomes involved in the complexities of Harry MacKenzie's life.

Ally Sheedy plays Helen, a character intertwined in the emotional journey of Harry MacKenzie.

Stephen Lang takes on the role of Keith, a character who interacts with Harry MacKenzie amidst his personal struggles.

Brian Dennehy portrays Nick, a character whose presence impacts Harry MacKenzie's life decisions.

Darrell Larson plays Jerry, a character connected to the unfolding events in Harry MacKenzie's life.

Christopher Parker takes on the role of Tim, a character who plays a part in the story of Harry MacKenzie.

Rachel Street portrays Joanne, a character involved in the intricate relationships within the film.

Kevin Bleyer plays Chris, a character whose interactions add depth to the narrative of Twice in a Lifetime.

Micole Mercurio portrays Betty, a character who contributes to the emotional dynamics of the story.