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Osmosis Jones
Cast
86 cast members · 37 with popularity data
Movie Stats
Top Cast
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Full Cast
Sorted by Buzz Score · April 29, 2026
1
William Shatner
Mayor Phlegmming (voice)
4.9
#640 overall
2
Kid Rock
Kidney Rock (voice)
4.2
#838 overall
3
Ron Howard
Tom Colonic (voice)
3.5
#1,144 overall
4
Bill Murray
Frank Detorre
3.0
#1,482 overall
5
Brandy Norwood
Leah (voice)
2.7
#1,762 overall
6
Laurence Fishburne
Thrax (voice)
2.2
#2,351 overall
7
Chris Rock
Osmosis Jones (voice)
2.1
#2,549 overall
8
Chris Elliott
Bob
1.8
#3,082 overall
9
Molly Shannon
Mrs. Boyd
1.3
#4,317 overall
10
David Hyde Pierce
Drix (voice)
1.3
#4,439 overall
11
Carlos Alazraqui
Spanish Germ (voice)
0.5
#10,091 overall
12
Uncle Kracker
Kidney Rock Band (voice)
0.5
#10,436 overall
13
Richard Steven Horvitz
Additional Character Voices (voice)
0.4
#12,120 overall
14
Rif Hutton
Charlie (voice)
0.4
#12,702 overall
15
Antonio Fargas
Chill the Flu Shot (voice)
0.4
#13,320 overall
16
Jonathan Adams
Officer Tom (voice)
0.3
#13,397 overall
17
Zak Penn
ER Doctor #3
0.3
#13,429 overall
18
Robert Wisdom
Big Germ (voice)
0.3
#13,740 overall
19
Rodger Bumpass
Joe Cramp / Announcer for Nerve News Network (voice)
0.3
#14,187 overall
20
Anne Lockhart
Female Red Blood Cell (voice)
0.3
#14,737 overall
21
Joe C.
Kidney Rock Band (voice)
0.3
#15,843 overall
22
Joel Silver
Police Chief (voice) (uncredited)
0.3
#16,026 overall
23
John Melendez
Artie (voice)
0.2
#20,801 overall
24
Zen Gesner
ER Doctor #1
0.1
#24,020 overall
25
Donald Fullilove
Doughnut (voice)
0.1
#28,466 overall
26
Steve Susskind
Mob Boss Germ (voice)
0.1
#33,220 overall
27
Chris Phillips
Firefighter Doug (voice)
0.1
#34,392 overall
28
Paul Pape
Male Red Blood Cell #2 (voice)
0.0
#36,048 overall
29
Doug Stone
Police Officer Jamie (voice)
0.0
#39,025 overall
30
Marc Hyman
ER Doctor #2
0.0
#39,824 overall
31
Paul Christie
Dan Matter / Germ (voice)
0.0
#40,116 overall
32
Eddie Frierson
Frank Police Department Officer (voice)
0.0
#40,268 overall
33
Sherry Lynn
Trudy (voice)
0.0
#41,884 overall
34
David Ossman
Scabies (voice) (uncredited)
0.0
#42,108 overall
35
Eddie Barth
Conductor (voice)
0.0
#42,490 overall
36
Al Rodrigo
Frank Police Department Walkie Talkie (voice)
0.0
#51,822 overall
37
Danny Murphy
Zookeeper Superintendent
0.0
#58,237 overall
38
Elena Franklin
Shane Detorre
—
39
Mickie McGowan
Additional Character Voice (voice)
—
40
Keith Anthony
Additional Character Voices (voice)
—
41
Sally Brooks
Additional Character Voices (voice)
—
42
Michael Carven
Additional Character Voices (voice)
—
43
Janis Dardaris
Additional Character Voices (voice)
—
44
Wendy Dillon
Additional Character Voices (voice)
—
45
Jackie Gonneau
Additional Character Voices (voice)
—
46
Shannon Gregory
Additional Character Voices (voice)
—
47
Art Kimbro
Additional Character Voices (voice)
—
48
Joyce Kurtz
Additional Character Voices (voice)
—
49
Danny Mann
Musician Cell (voice)
—
50
Kenny Olson
Kidney Rock Band (voice)
—
51
Jason Krause
Kidney Rock Band (voice)
—
52
Stefanie Eulinberg
Kidney Rock Band (voice)
—
53
Jimmie Bones
Kidney Rock Band (voice)
—
54
Héctor Mercado
Additional Character Voices (voice)
—
55
Marilyn Pasekoff
Additional Character Voices (voice)
—
56
Lynne Redding
Additional Character Voices (voice)
—
57
Herschel Sparber
Bruiser (voice)
—
58
Keri Tombazian
Additional Character Voices (voice)
—
59
Paul Tuerpe
Additional Character Voices (voice)
—
60
Jack McCullough
Zookeeper
—
61
Will Dunn
Oyster Boy
—
62
Jackie Flynn
School Janitor
—
63
Kelsey Jordan
Bus Girl #1
—
64
Abe Farrelly
Bus Girl #2
—
65
Jesse Peter
Laughing Boy
—
66
John-Eliot Jordan
Pea Soup Manager
—
67
Nancy Byers
Pea Soup Supervisor
—
68
Kevin J. Flynn
Docky's Clamshack Waiter
—
69
Sean Gildea
Dreamy Photographer
—
70
Kathryn Frick
Nurse #1
—
71
Nikki Tyler-Flynn
Nurse #2
—
72
Elizabeth Jordan
Nurse #3
—
73
Diane Conrad
Zoo Visitor or Staff
—
74
Judith Conrad
Zoo Visitor or Staff
—
75
Thomas Jordan
The Zoo Visitor or Staff
—
76
Sydney J. Bartholomew Jr.
Zoo Visitor or Staff
—
77
Erica Johnson
Zoo Visitor or Staff
—
78
Bo Cleary
Pea Soup Staff
—
79
Bruce McIntyre
Pea Soup Staff
—
80
Colleen O'Donnell
Docky's Clamshack
—
81
Docky
The Bikini Gang
—
82
Joe Murphy
The Bikini Gang
—
83
Brian Mone
Police Officer
—
84
Sean Fitzgerald
Police Officer
—
85
Grace Costa
ER Nurse
—
86
Emily O’Donnell
School Girl
—
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