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Annihilation
Cast
19 cast members · 12 with popularity data
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Sorted by Buzz Score · April 30, 2026
1
Oscar Isaac
Kane
11.4
#120 overall
2
Natalie Portman
Lena
6.6
#360 overall
3
Jennifer Jason Leigh
Dr Ventress
4.3
#811 overall
4
Tessa Thompson
Josie Radek
2.4
#2,063 overall
5
Benedict Wong
Lomax
1.6
#3,386 overall
6
Gina Rodriguez
Anya Thorensen
1.2
#4,579 overall
7
Sonoya Mizuno
Humanoid / Katie (Med Student)
1.2
#4,752 overall
8
Cosmo Jarvis
Special Ops Soldier (uncredited)
1.1
#5,011 overall
9
Tuva Novotny
Cass Sheppard
0.6
#8,782 overall
10
David Gyasi
Daniel
0.4
#12,223 overall
11
Kola Bokinni
Peyton (uncredited)
0.3
#14,404 overall
12
John Schwab
Paramedic
0.1
#33,864 overall
13
Sammy Hayman
Mayer
—
14
Josh Danford
Shelley
—
15
Kristen McGarrity
Lena Double
—
16
Kumud Pant
Scientist
—
17
Honey Holmes
Scientist (uncredited)
—
18
Hiten Patel
Scientist (uncredited)
—
19
Matthew Simpson
Special Ops Soldier (uncredited)
—
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